发给老马备查:
$ T6 T8 p+ `2 l& p# C9 f6 j4 `滴水察海(69304838) 15:23:23
' x9 o# Q" `3 Q( r9 Q3 e1 `老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱$ B# r# |; a _. {2 y$ C8 C2 j
吉非替尼和S-1连用的依据
2 h& O/ N [3 G7 l6 O* F: ?Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' q% v+ V, c# Z( G+ n# b0 u是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
( V/ e, f5 T2 _$ L7 J* E这样是不是推理出,耐药后,可以用S-1和培美了?
- }) B8 {: P! ~, G7 E0 z结论:
B7 B6 G& `1 n如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |