发给老马备查: z% D2 q2 L" u. F# L5 b- v3 j
滴水察海(69304838) 15:23:230 Y c% e$ @- i# r% X' Q9 A
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱5 B, B( ~8 A4 C& ?0 W
吉非替尼和S-1连用的依据
: t5 z. _" d" |& ~: |' tGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., s* o: T3 s- W
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
; |3 Q+ i/ `7 `这样是不是推理出,耐药后,可以用S-1和培美了?
0 C7 {5 {6 ^5 C# R1 x! ~( \& [4 G) F1 \结论:
7 B) X @7 O% r$ y" F1 q如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |