发给老马备查:
0 o& H! w& ~* o; x- @% }滴水察海(69304838) 15:23:23
% j5 e) ~! b- B- ]老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱! Y" i9 K/ r& g% s/ G$ s( R
吉非替尼和S-1连用的依据
. L! h/ O/ q- r, f7 w9 g5 WGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.* m' b% R! R q7 W, A) X2 V
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
- t7 G8 X, T3 M! M! z7 g$ S这样是不是推理出,耐药后,可以用S-1和培美了?
; N! a7 y; V$ C结论:
/ h1 `) d' d+ D* q9 I+ ?) {. S如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |