发给老马备查:
) k; V+ F+ K3 M2 E$ ^滴水察海(69304838) 15:23:23) R9 n2 W5 ]3 H+ o
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
5 `. @& r1 E7 }- d# g1 }6 I4 W吉非替尼和S-1连用的依据
* D' @, a1 K5 N: _! w) yGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.: O1 w4 ?$ m4 o
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
; J* P9 R8 L1 Z, W' R1 A" K这样是不是推理出,耐药后,可以用S-1和培美了?$ |; J$ I! w; ^0 H/ {8 j
结论:, k' _8 q# k$ o5 r5 B7 Z- }: q* o
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |