发给老马备查:; M! X& M0 j8 O
滴水察海(69304838) 15:23:232 N( }* m' c1 ]: J6 N; B, ], Y
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
* P7 h/ m' M# j0 G/ {/ X吉非替尼和S-1连用的依据
6 ^) ] ?; p4 P" N- l+ q% B8 U5 ? jGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ ~$ g# G; n' |是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达+ ?% m. ^) c3 m
这样是不是推理出,耐药后,可以用S-1和培美了?3 B! `! _9 e: m, c% a
结论:
# B- ?8 U! a, I6 y如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |