看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。. U* x7 w9 M2 o# B
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- D4 p& C0 C+ V" o* xCurrently available feasibility data for possible combination strategies. ! R0 m) Z" Q! W3 |4 E* m9 N9 O& ]
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Combination Feasibility according to preliminary data 0 ?$ j! @3 Q- m; U7 e9 m; l
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" ~, [" i5 j& I+ { F" \5 B% G9 [Bevacizumab + sorafenib Yes, reduced dose 1 j! N7 n/ E4 D: G7 g/ [
Bevacizumab + sunitinib† No 9 U; U, [' D7 _+ a0 ?! Y( H
Bevacizumab + temsirolimus Yes + R1 N$ k* l: S0 p5 H! G
Bevacizumab + everolimus Yes 0 e! Q; @: U2 r A- R4 ^$ ]3 U
Sorafenib + sunitinib ?
8 s5 L9 g: | x9 F4 \- ASorafenib + temsirolimus Yes, reduced dose
5 v9 F( I: Q+ y: l# E1 OSorafenib + everolimus Yes, reduced dose
/ Y, {6 w: \; C: r2 xSunitinib + temsirolimus† No
! ^8 t3 u. l' H k0 ]0 }Sunitinib + everolimus ? / @# C$ S! a9 h1 c6 ?) L
Temsirolimus + everolimus ?
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†Led to US FDA warning.% A; K$ g6 J& [; I3 x3 ?1 h# E- h
?: As yet unattempted combination.
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