看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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3 W8 D5 F# G( G+ ~Currently available feasibility data for possible combination strategies. 0 i$ d* m7 d2 S2 S j
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Combination Feasibility according to preliminary data ?" n/ X7 T1 ^' v
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# R: Z( U* n' P, R9 @Bevacizumab + sorafenib Yes, reduced dose
7 f& s& [ j7 }Bevacizumab + sunitinib† No . |. d# c% o7 _' n5 Z7 B
Bevacizumab + temsirolimus Yes
9 \/ X. x2 V1 c9 W" Q5 }3 YBevacizumab + everolimus Yes
9 G- ?0 L ^, x1 DSorafenib + sunitinib ?
9 p3 R. u) B g) GSorafenib + temsirolimus Yes, reduced dose
7 t! I6 Z% |- k6 V" M7 X3 q1 S6 }% Y+ qSorafenib + everolimus Yes, reduced dose
' p0 Y0 ~+ M" {) gSunitinib + temsirolimus† No ! Z. b8 p" H$ e6 @( e5 W
Sunitinib + everolimus ? : H9 {3 J7 g2 z( R. d* M
Temsirolimus + everolimus ? / q+ j" R, S# z6 {6 S! j+ _
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# f+ p9 `8 a8 I5 {†Led to US FDA warning.
: }9 X9 g3 ~: s?: As yet unattempted combination.1 B$ Z( d$ f# Z! t& \4 ^
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